Natural Products are produced by every living organism and are therefore ubiquitous in life. Each one has its own purpose, from structure-giving building blocks and metabolic intermediates to signaling and protection systems. Although their original purpose is not necessarily known, many of them show biological and pharmacological activity in the human body. Since centuries, pain-relieving or soothing plant extracts were used to treat various ailments. Modern methods such as liquid chromatography (LC) and nuclear magnetic resonance spectroscopy (NMR) allow the isolation and characterization of new complex natural products. With known structure, the synthesis of such natural products can be realized. We focus on the total synthesis of biologically active natural products and novel methods to build specific structural motifs.
 D. Martin, J. Für Prakt. ChemieChemiker-Ztg. 1998, 340, 585–585.
Anti-Malaria Natural Products [Benedikt Kolb, Marcel Freund]
Malaria is a foremost tropical illness, being responsible for about 435.000 deaths each year. The disease is caused by parasites of the Plasmodium species that are transmitted to humans via mosquito stings. By today malaria can be treated with several natural-product based medications such as chloroquine and artemisinin. However, drug resistances in Plasmodia increase since many years. Additionally, due to the climate change the transmitting mosquitos become endemic to moderate climate zones. To treat malaria infections, it is therefore important to get access to new active compounds.[2,3]
Our goal is to develop reliable synthetic routes to various anti plasmodial natural products for biological testing.
Polycyclic Natural Products [Yannick Stöckl]
Polycyclic natural products such as spinosyn or clifednamide display promising biological activities and their intriguing structures provide challenging synthetic projects. Hence, we investigate the use of tetrahydroindanones in the efficient synthesis of polycyclic scaffolds via the Diels-Alder reaction. Further projects include the step-economic total synthesis of bicyclic natural products and chiral boron reagents in organic chemistry. To perform these challenging syntheses, Schlenk technique, column chromatography as well as HPLC are employed and compound analysis is achieved mainly by (hetero nuclear) NMR, supported by MS and X-ray diffraction and computation.
 Y. Stöckl, W. Frey, J. Lang, B. Claasen, A. Baro, S. Laschat, Synthesis 2019, 51, 1123–1134.
Antibiotic Natural Products [Andreas Greulich]
Rising antibiotic resistance is a threat to everyone, leading to hard or non-treatable bacterial infections that cause higher medical costs and a rising mortality. For new treatments, the approach via host-pathogen-interactions is promising. During a bacterial infection host cells withdraw essential nutrients, e.g. Fe3+/2+, to protect themselves. To overcome, this lack of iron, bacteria produce iron binding natural products, such as aerobactin, enterobactin and staphyloferrin A, so called siderophores.[6,7] Inspired by these siderophores; iron binding natural products and their derivatives are aimed to be synthesized by our group. Due to the iron complexation, these molecules should show antibiotic effects.
 Link (WHO) (30.11.2020).
 U. Bilitewski, J. A. V. Blodgett, A.-K. Duhme‐Klair, S. Dallavalle, S. Laschat, A. Routledge, R. Schobert, Angew. Chem. 2017, 129, 14552–14575.
 M. Miethke, M. A. Marahiel, Microbiol. Mol. Biol. Rev. 2007, 71, 413–451.